Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion
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چکیده
منابع مشابه
Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion.
Advanced oxidation protein products (AOPPs), a protein biomarker of increased oxidative stress, are elevated in uremic patients. Zhou et al. demonstrate that chronic administration of AOPPs induces podocyte apoptosis and proteinuria in normal rats via a cascade of signaling events. This study for the first time establishes a causative link between oxidative stress and podocyte depletion and cou...
متن کاملAdvanced oxidation protein products as a novel molecular basis of oxidative stress in uraemia.
status in chronic renal failure. Indeed, we described Oxidative stress in uraemia syndrome for the first time, the presence in the plasma of haemodialysed patients high levels of oxidized proteins that Considerable evidence has accumulated that chronic we designated AOPPs [11]. Since oxidative damage to uraemia is associated with a multifactorial immunoproteins modifies the spectroscopic charac...
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BACKGROUND Advanced oxidation protein products (AOPPs) are acknowledged as a novel marker of oxidation-mediated protein damage. This study aimed to investigate the plasma levels of AOPPs in postmenopausal osteoporotic women, and to determine the relationship between AOPPs accumulation and lumbar bone mineral destiny (BMD) or bone turnover markers. MATERIAL AND METHODS Lumbar BMD was measured ...
متن کاملAdvanced oxidation protein products accelerate atherosclerosis through promoting oxidative stress and inflammation.
OBJECTIVE Increased level of plasma advanced oxidation protein products (AOPPs) has been found in patients with uremia and nonuremic subjects with coronary artery disease. This study was conducted to test the hypothesis that AOPPs play a causal role in atherosclerosis. METHODS AND RESULTS Hypercholesterolemic (0.5% wt/wt diet) or normal rabbits received either repeated intravenous injections ...
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Focal segmental glomerular sclerosis (FSGS) is a primary kidney disease that is commonly associated with proteinuria and progressive loss of glomerular function, leading to development of chronic kidney disease (CKD). FSGS is characterized by podocyte injury and depletion and collapse of glomerular capillary segments. Progression of FSGS is associated with TGF-β activation in podocytes; however...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2009
ISSN: 0085-2538
DOI: 10.1038/ki.2009.352